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Trifluoperazine inhibits acetaminophen-induced hepatotoxicity and hepatic reactive nitrogen formation in mice and in freshly isolated hepatocytes

  • Published:2017 Issue: Volume:4 Page:134-142
  • ISSN:2214-7500
  • Container-title:Toxicology Reports
  • language:en
  • Short-container-title:Toxicology Reports

Author:

Banerjee Sudip,Melnyk Stepan B.,Krager Kimberly J.,Aykin-Burns Nukhet,McCullough Sandra S.,James Laura P.,Hinson Jack A.

Funder

National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases to JAH

National Institute of Environmental Health Sciences

National Institute of General Medical Sciences

Arkansas Science and Technology Authority

Arkansas Biosciences Institute

Publisher

Elsevier BV

Subject

Health, Toxicology and Mutagenesis,Toxicology

Reference57 articles.

1. Acetaminophen-induced hepatotoxicity;James;Drug Metab. Dispos.,2003

2. Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism;Mitchell;J. Pharmcol. Exp. Ther.,1973

3. Acute liver failure: summary of a workshop;Lee;Hepatology,2008

4. N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen;Dahlin;Proc. Natl. Acad. Sci. U. S. A.,1984

5. Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen;Jollow;Pharmacology,1974
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