Preclinical toxicology and safety pharmacology of the first-in-class GADD45β/MKK7 inhibitor and clinical candidate, DTP3-Reference-Cited by-同舟云学术

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Preclinical toxicology and safety pharmacology of the first-in-class GADD45β/MKK7 inhibitor and clinical candidate, DTP3

Published:2019 Issue: Volume:6 Page:369-379
ISSN:2214-7500
Container-title:Toxicology Reports
language:en
Short-container-title:Toxicology Reports

Author:

Tornatore Laura,Capece Daria,D'Andrea Daniel,Begalli Federica,Verzella Daniela,Bennett Jason,Acton Gary,Campbell Elizabeth A.,Kelly James,Tarbit Michael,Adams Nigel,Bannoo Selina,Leonardi Antonio,Sandomenico Annamaria,Raimondo Domenico,Ruvo Menotti^ORCID,Chambery Angela^ORCID,Oblak Metod,Al-Obaidi Magda J.,Kaczmarski Richard S.,Gabriel Ian,Oakervee Heather E.,Kaiser Martin F.,Wechalekar Ashutosh,Benjamin Reuben,Apperley Jane F.,Auner Holger W.^ORCID,Franzoso Guido

Funder

Cancer Research UK programme

Medical Research Council (MRC) Biomedical Catalyst

Bloodwise project

Cancer Research UK Clinician Scientist Fellowship

Publisher

Elsevier BV

Subject

Health, Toxicology and Mutagenesis,Toxicology

Reference36 articles.

1. Oncogenic activation of NF-κB;Staudt;Cold Spring Harb. Perspect. Biol.,2010

2. NF-κB and the link between inflammation and cancer;DiDonato;Immunol. Rev.,2012

3. Is NF-κB a good target for cancer therapy? Hopes and pitfalls;Baud;Nat. Rev. Drug Discov.,2009

4. Turning an old GADDget into a troublemaker;Capece;Cell Death Differ.,2018

5. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB;DiDonato;Nature,1997

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