Two distinct pathways for cAMP-mediated down-regulation of the β2-adrenergic receptor-Reference-Cited by-同舟云学术

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Two distinct pathways for cAMP-mediated down-regulation of the β2-adrenergic receptor

Published:1989-10 Issue:28 Volume:264 Page:16786-16792
ISSN:0021-9258
Container-title:Journal of Biological Chemistry
language:en
Short-container-title:Journal of Biological Chemistry

Author:

Bouvier M,Collins S,O'Dowd B F,Campbell P T,de Blasi A,Kobilka B K,MacGregor C,Irons G P,Caron M G,Lefkowitz R J

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference42 articles.

1. Regulation of Adenylyl Cyclase-Coupled beta-Adrenergic Receptors

2. Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein.

3. Regulation of adrenergic receptor function by phosphorylation. II. Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase.

4. Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein).

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