Biosynthesis of the unusual amino acid (4R)-4-[(E)-2-butenyl]-4-methyl-L-threonine of cyclosporin A. Identification of 3(R)-hydroxy-4(R)-methyl-6(E)-octenoic acid as a key intermediate by enzymatic in vitro synthesis and by in vivo labeling techniques.-Reference-Cited by-同舟云学术

Biosynthesis of the unusual amino acid (4R)-4-[(E)-2-butenyl]-4-methyl-L-threonine of cyclosporin A. Identification of 3(R)-hydroxy-4(R)-methyl-6(E)-octenoic acid as a key intermediate by enzymatic in vitro synthesis and by in vivo labeling techniques.

Published:1993-12 Issue:35 Volume:268 Page:26127-26134
ISSN:0021-9258
Container-title:Journal of Biological Chemistry
language:en
Short-container-title:Journal of Biological Chemistry

Author:

Offenzeller M,Su Z,Santer G,Moser H,Traber R,Memmert K,Schneider-Scherzer E

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference33 articles.

1. Ciclosporin Progress in Allergy;Wartburg,1986

2. Cyclosporin A: recent developments in the mechanism of action and clinical application

3. Cyclosporin synthetase. The most complex peptide synthesizing multienzyme polypeptide so far described.

4. Cell-free biosynthesis of new cyclosporins.

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