Immunoglobulin M possesses two binding sites for complement subcomponent C1q, and soluble 1:1 and 2:1 complexes are formed in solution at reduced ionic strength.-Reference-Cited by-同舟云学术

Immunoglobulin M possesses two binding sites for complement subcomponent C1q, and soluble 1:1 and 2:1 complexes are formed in solution at reduced ionic strength.

Published:1985-08 Issue:16 Volume:260 Page:9357-9365
ISSN:0021-9258
Container-title:Journal of Biological Chemistry
language:en
Short-container-title:Journal of Biological Chemistry

Author:

Poon P H,Phillips M L,Schumaker V N

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference37 articles.

1. The reaction of monomeric and aggregated immunoglobulins with Cl

2. Complement Fixation on Cell Surfaces by 19 S and 7 S Antibodies

3. Distinction between fixation of C1 and the activation of complement by natural IgM anti-hapten antibody: Effect of cell surface hapten density

4. Activation of antibody Fc function by antigen-induced conformational changes.

5. Evidence for a long-range conformational change induced by antigen binding to IgM antibody.

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