Effect of Antioxidants Supplementation on Erectile Dysfunction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Author:
Su Liang12, Yang Zhao-tian3, Qu Hua42, Luo Cheng-long12, Yuan Guo-xing12, Wu Jie12, Jiao Yong-zheng1252
Affiliation:
1. Guang'anmen Hospital , , Beijing , China 2. China Academy of Chinese Medical Sciences , , Beijing , China 3. The Affiliated Hospital of Shaanxi University of Chinese Medicine , Xianyang , China 4. Xiyuan Hospital , , Beijing , China 5. Institute of Acupuncture and Moxibustion , , Beijing , China
Abstract
Abstract
Introduction
In Erectile dysfunction (ED) patients, phosphodiesterase type 5 (PDE5) inhibitors are considered as the first-line therapy. However, 30–50% of ED patients fail to follow this therapeutic option because of adverse events, lack of efficacy, or drug costs. Antioxidant supplementation is widely applied in clinical practice and viewed as a potential therapeutic option for ED. Therefore, it is attractive to assess the effect of antioxidants supplementation on ED patients.
Objectives
To evaluate the effects of antioxidants supplementation on ED.
Methods
Published randomized controlled trials of antioxidants in ED were searched in the PubMed, Embase, and Cochrane Library databases from inception to October 3, 2021. Meta-analyses were carried out using a random-effects model. The results were presented as standard mean differences (SMDs) with their 95% confidence intervals (CIs).
Results
Eighteen studies with 1,331 ED patients were included in the study. Compared with placebo, antioxidants alone treatment showed a statistical increase in International Index of Erectile Function (IIEF) score (SMD = 1.93; 95% CI: 0.15, 3.72; P = .034). Compared with placebo, antioxidants compound treatment elicited a significant increase in IIEF score (SMD = 2.74; 95% CI: 1.67, 3.81; P < .001) as well as sexual satisfaction score (SMD = 1.61; 95% CI: 0.63, 2.59; P = .001). Compared with the PDE5 inhibitors alone, combination of PDE5 inhibitors and antioxidants showed a significant increase in IIEF score (SMD = 1.1; 95% CI: 0.51, 1.68; P < .001) and sexual satisfaction score (SMD = 1.28; 95% CI: 0.06, 2.51; P = .04).
Conclusion
This study found that the effect of antioxidant alone treatment on ED may be limited. However, antioxidant compound treatment, as well as combination of PDE5 inhibitors and antioxidants, were associated with improved ED, and can be considered as an accessary therapeutic option for ED.
Funder
National Natural Science Foundation of China Scientific and technological innovation project of China Academy of Chinese Medical Sciences
Publisher
Oxford University Press (OUP)
Subject
Urology,Obstetrics and Gynecology,Reproductive Medicine,Endocrinology,Endocrinology, Diabetes and Metabolism,Psychiatry and Mental health
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