Enhanced signaling via ERBB3/PI3K plays a compensatory survival role in pancreatic tumor cells exposed to [neratinib + valproate]

Author:

Dent Paul,Booth Laurence,Poklepovic Andrew,Hoff Daniel Von,Hancock John F.

Funder

Massey Cancer Center and the Universal Inc.

Commonwealth Health Research Board

Publisher

Elsevier BV

Subject

Cell Biology

Reference27 articles.

1. Dent P. HDAC inhibitors enhance neratinib activity and when combined enhance the actions of an anti-PD-1 immunomodulatory antibody in vivo;Booth;Oncotarget,2017

2. Neratinib augments the lethality of [regorafenib+sildenafil];Booth;J. Cell. Physiol.,2019

3. [Neratinib + Valproate] exposure permanently reduces ERBB1 and RAS expression in 4T1 mammary tumors and enhances M1 macrophage infiltration;Booth;Oncotarget.,2017

4. Neratinib and Entinostat combine to rapidly reduce the expression of K-RAS, N-RAS, Gαq and Gα11 and kill uveal melanoma cells;Booth;Cancer Biol. Ther.,2018

5. The role of cell signaling in the crosstalk between autophagy and apoptosis in the regulation of tumor cell survival in response to sorafenib and neratinib;Booth;Semin. Cancer Biol.,2019

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