Interleukin 1 β-induced SMAD2/3 linker modifications are TAK1 dependent and delay TGFβ signaling in primary human mesenchymal stem cells

Author:

van den Akker Guus G.,van Beuningen Henk M.,Vitters Elly L.,Koenders Marije I.,van de Loo Fons A.,van Lent Peter L.,Blaney Davidson Esmeralda N.,van der Kraan Peter M.ORCID

Funder

UK/MRC

Dutch Arthritis Foundation

Publisher

Elsevier BV

Subject

Cell Biology

Reference58 articles.

1. Acquiring chondrocyte phenotype from human mesenchymal stem cells under inflammatory conditions;Kondo;Int. J. Mol. Sci.,2014

2. Catabolic factors and osteoarthritis-conditioned medium inhibit chondrogenesis of human mesenchymal stem cells;Heldens;Tissue Eng. A,2011

3. Mechanisms of TGF-beta signaling from cell membrane to the nucleus;Shi;Cell,2003

4. Human Smad3 and Smad4 are sequence-specific transcription activators;Zawel;Mol. Cell,1998

5. Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFβ/ALK5 signaling;Goumans;Mol. Cell,2003

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