ABCB1 restricts brain accumulation of the novel RORγ agonist cintirorgon, while OATP1A/1B and CYP3A limit its oral availability-Reference-Cited by-同舟云学术

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ABCB1 restricts brain accumulation of the novel RORγ agonist cintirorgon, while OATP1A/1B and CYP3A limit its oral availability

Published:2022-08 Issue: Volume:177 Page:135-146
ISSN:0939-6411
Container-title:European Journal of Pharmaceutics and Biopharmaceutics
language:en
Short-container-title:European Journal of Pharmaceutics and Biopharmaceutics

Author:

Li Wenlong,Lehutová Daniela,Sparidans Rolf W.,Heydari Paniz,Wang Jing,Lebre Maria C.,Beijnen Jos H.,Schinkel Alfred H.

Funder

China Scholarship Council

Publisher

Elsevier BV

Subject

Pharmaceutical Science,General Medicine,Biotechnology

Reference36 articles.

1. Retinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and Metabolism;Cook;Nucl. Receptor. Res.,2015

2. Requirement for RORgamma in thymocyte survival and lymphoid organ development;Sun;Science,2000

3. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells;Ivanov;Cell,2006

4. Construction of triple-transfected cells [organic anion-transporting polypeptide (OATP) 1B1/multidrug resistance-associated protein (MRP) 2/MRP3 and OATP1B1/MRP2/MRP4] for analysis of the sinusoidal function of MRP3 and MRP4;Hirouchi;Drug. Metab. Dispos.,2009

5. Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments;Kryczek;Blood,2009

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Discovery, structural optimization, and anti-tumor bioactivity evaluations of betulinic acid derivatives as a new type of RORγ antagonists;European Journal of Medicinal Chemistry;2023-09

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