Computational fluid dynamic simulations of temperature, cryoconcentration, and stress time during large-scale freezing and thawing of monoclonal antibody solutions
Author:
Publisher
Elsevier BV
Subject
Pharmaceutical Science,General Medicine,Biotechnology
Reference7 articles.
1. Effect of Freezing Rate and Dendritic Ice Formation on Concentration Profiles of Proteins Frozen in Cylindrical Vessels;Rodrigues;J. Pharm. Sci.,2011
2. Cryoconcentration and 3D Temperature Profiles During Freezing of mAb Solutions in Large-Scale PET Bottles and a Novel Scale-Down Device;Bluemel;Pharm. Res.,2020
3. A New Perspective on Scale-Down Strategies for Freezing of Biopharmaceutics by Means of Computational Fluid Dynamics;Geraldes;J. Pharm. Sci.,2020
4. Scaling Down Large-Scale Thawing of Monoclonal Antibody Solutions: 3D Temperature Profiles, Changes in Concentration, and Density Gradients;Bluemel;Pharm. Res.,2021
5. Large-Scale Freezing of Biologics A Practitioner’s Review, Part One: Fundamental Aspects;Singh;Bioprocess Int.,2009
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1. High concentration formulation developability approaches and considerations;mAbs;2023-05-16
2. An Intra-Company Analysis of Inherent Particles in Biologicals Shapes the Protein Particle Mitigation Strategy Across Development Stages;Journal of Pharmaceutical Sciences;2023-05
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