Tumor microenvironment determines drug efficacy in vitro - apoptotic and anti-inflammatory effects of 15-lipoxygenase metabolite, 13-HpOTrE

Author:

Wolff Christopher,Zoschke Christian,Kalangi Suresh Kumar,Reddanna Pallu,Schäfer-Korting Monika

Funder

Federal Ministry of Education and Research, Germany

Berlin-Brandenburg research platform BB3R

Publisher

Elsevier BV

Subject

Pharmaceutical Science,General Medicine,Biotechnology

Reference44 articles.

1. Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate;Brash;J. Biol. Chem.,1999

2. Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells;Pidgeon;Cancer Res.,2002

3. Lipoxygenase metabolism: roles in tumor progression and survival;Pidgeon;Cancer Metastasis Rev.,2007

4. Inverse relationship between 15-lipoxygenase-2 and PPAR-γ gene expression in normal epithelia compared with tumor epithelia;Subbarayan;Neoplasia.,2005

5. Lipoxygenase modulation to reverse carcinogenesis;Shureiqi;Cancer Res.,2001

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