The immunogenicity of an anti-EGFR single domain antibody (VHH) is enhanced by misfolded amorphous aggregation but not by heat-induced aggregation
Author:
Funder
JSPS
MEXT
TUAT
Publisher
Elsevier BV
Subject
Pharmaceutical Science,General Medicine,Biotechnology
Reference55 articles.
1. Protein therapeutics: a summary and pharmacological classification;Leader;Nat. Rev. Drug Discovery,2008
2. Effects of protein aggregates: an immunologic perspective;Rosenberg;AAPS J.,2006
3. Pure red-cell aplasia and antierythropoietin antibodies in patients treated with recombinant erythropoietin;Casadevall;N. Engl. J. Med.,2002
4. Immunogenicity of therapeutic proteins: clinical implications and future prospects;Schellekens;Clin. Ther.,2002
5. Assessment and reporting of the clinical immunogenicity of therapeutic proteins and peptides-harmonized terminology and tactical recommendations;Shankar;AAPS J.,2014
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