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5. Industry databases used are: Investigational Drugs database, Thomson Current Drugs, 14 Great Queen Street, London WC2B 5DF, United Kingdom; BioSpace Clinical Competitive Intelligence System, BioSpace, 300 Fifth Ave. South, Naples, FL 34102, USA; and IMS Lifecycle, IMS Health, 7 Harewood Avenue, London NW1 6JB, United Kingdom.