Microcrystalline cellulose, a useful alternative for sucrose as a matrix former during freeze-drying of drug nanosuspensions – A case study with itraconazole

Author:

Bernard Van Eerdenbrugh,Sofie Vercruysse,A Martens Johan,Jan Vermant,Ludo Froyen,Jan Van Humbeeck,Guy Van den Mooter,Patrick Augustijns

Publisher

Elsevier BV

Subject

Pharmaceutical Science,General Medicine,Biotechnology

Reference21 articles.

1. Poor aqueous solubility – an industry wide problem in drug discovery;Lipinski;Am. Pharm. Rev.,2002

2. Nanosuspensions in drug delivery;Rabinow;Nat. Rev. Drug Discov.,2004

3. Manufacturing of nanoparticles by milling and homogenization techniques;Müller,2006

4. Nanosizing – oral formulation development and biopharmaceutical evaluation;Kesisoglou;Adv. Drug Deliv. Rev.,2007

5. Nanosuspensions: a promising drug delivery strategy;Patravale;J. Pharm. Pharmacol.,2004

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