Lipophilic salts of poorly soluble compounds to enable high-dose lipidic SEDDS formulations in drug discovery

Author:

Morgen Michael,Saxena Ajay,Chen Xue-Qing,Miller Warren,Nkansah Richard,Goodwin Aaron,Cape Jon,Haskell Roy,Su Ching,Gudmundsson Olafur,Hageman Michael,Kumar Anoop,Chowan Gajendra Singh,Rao Abhijith,Holenarsipur Vinay K.

Publisher

Elsevier BV

Subject

Pharmaceutical Science,General Medicine,Biotechnology

Reference51 articles.

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2. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings;Lipinski;Adv. Drug Del. Rev.,2012

3. Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs;Porter;Nat. Rev. Drug Disc.,2007

4. The application of discovery toxicology and pathology toward the design of safer pharmaceutical lead candidates;Kramer;Nat. Rev. Drug Disc.,2007

5. Micronization: a method of improving the bioavailability of poorly soluble drugs;Chaumeil;Methods Find. Exp. Clin. Pharmacol.,1998

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