Impact of heat treatment on miscibility of proteins and disaccharides in frozen solutions

Author:

Izutsu Ken-ichi,Yomota Chikako,Okuda Haruhiro,Kawanishi Toru,Randolph Theodore W.,Carpenter John F.

Publisher

Elsevier BV

Subject

Pharmaceutical Science,General Medicine,Biotechnology

Reference45 articles.

1. Mechanism of protein stabilization during freeze-drying and storage: the relative importance of thermodynamic stabilization and glassy state relaxation dynamics;Pikal,1999

2. Freezing- and drying-induced perturbations of protein structure and mechanisms of protein protection by stabilizing additives;Carpenter,1999

3. Physical factors affecting the storage stability of freeze-dried interleukin-1 receptor antagonist: glass transition and protein conformation;Chang;Arch. Biochem. Biophys.,1996

4. An infrared spectroscopic study of the interactions of carbohydrates with dried proteins;Carpenter;Biochemistry,1989

5. Stabilization of protein structure by solvent additives;Timasheff,1992

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