Three amino acid substitutions in the NS1 protein change the virus replication of H5N1 influenza virus in human cells

Author:

Li Jing,Zhang Kun,Chen Quanjiao,Zhang Xiaoshuang,Sun Yeping,Bi Yuhai,Zhang Shuang,Gu Jinyan,Li Jiarong,Liu Di,Liu Wenjun,Zhou Jiyong

Funder

National Key Research Program

National Natural Science Foundation of China

Southeast Asia Biodiversity Research Institute, Chinese Academy of Science

Strategic Priority Research Program of Chinese Academy of Sciences

Innovative Research Group of National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Virology

Reference44 articles.

1. A single amino acid substitution in the novel H7N9 influenza A virus NS1 protein increases CPSF30 binding and virulence;Ayllon;J. Virol.,2014

2. The NS1 protein: a multitasking virulence factor;Ayllon;Curr. Top. Microbiol. Immunol.,2015

3. Assessment of the internal genes of influenza A (H7N9) virus contributing to high pathogenicity in mice;Bi;J. Virol.,2015

4. A systems analysis identifies a feedforward inflammatory circuit leading to lethal influenza infection;Brandes;Cell,2013

5. Mammalian adaptation of an avian influenza A virus involves stepwise changes in NS1;Chauche;J. Virol.,2018

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