Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA

Author:

Liu M.C.,Oxnard G.R.,Klein E.A.,Swanton C.,Seiden M.V.,Liu Minetta C.,Oxnard Geoffrey R.,Klein Eric A.,Smith David,Richards Donald,Yeatman Timothy J.,Cohn Allen L.,Lapham Rosanna,Clement Jessica,Parker Alexander S.,Tummala Mohan K.,McIntyre Kristi,Sekeres Mikkael A.,Bryce Alan H.,Siegel Robert,Wang Xuezhong,Cosgrove David P.,Abu-Rustum Nadeem R.,Trent Jonathan,Thiel David D.,Becerra Carlos,Agrawal Manish,Garbo Lawrence E.,Giguere Jeffrey K.,Michels Ross M.,Harris Ronald P.,Richey Stephen L.,McCarthy Timothy A.,Waterhouse David M.,Couch Fergus J.,Wilks Sharon T.,Krie Amy K.,Balaraman Rama,Restrepo Alvaro,Meshad Michael W.,Rieger-Christ Kimberly,Sullivan Travis,Lee Christine M.,Greenwald Daniel R.,Oh William,Tsao Che-Kai,Fleshner Neil,Kennecke Hagen F.,Khalil Maged F.,Spigel David R.,Manhas Atisha P.,Ulrich Brian K.,Kovoor Philip A.,Stokoe Christopher,Courtright Jay G.,Yimer Habte A.,Larson Timothy G.,Swanton Charles,Seiden Michael V.,Cummings Steven R.,Absalan Farnaz,Alexander Gregory,Allen Brian,Amini Hamed,Aravanis Alexander M.,Bagaria Siddhartha,Bazargan Leila,Beausang John F.,Berman Jennifer,Betts Craig,Blocker Alexander,Bredno Joerg,Calef Robert,Cann Gordon,Carter Jeremy,Chang Christopher,Chawla Hemanshi,Chen Xiaoji,Chien Tom C.,Civello Daniel,Davydov Konstantin,Demas Vasiliki,Desai Mohini,Dong Zhao,Fayzullina Saniya,Fields Alexander P.,Filippova Darya,Freese Peter,Fung Eric T.,Gnerre Sante,Gross Samuel,Halks-Miller Meredith,Hall Megan P.,Hartman Anne-Renee,Hou Chenlu,Hubbell Earl,Hunkapiller Nathan,Jagadeesh Karthik,Jamshidi Arash,Jiang Roger,Jung Byoungsok,Kim TaeHyung,Klausner Richard D.,Kurtzman Kathryn N.,Lee Mark,Lin Wendy,Lipson Jafi,Liu Hai,Liu Qinwen,Lopatin Margarita,Maddala Tara,Maher M. Cyrus,Melton Collin,Mich Andrea,Nautiyal Shivani,Newman Jonathan,Newman Joshua,Nicula Virgil,Nicolaou Cosmos,Nikolic Ongjen,Pan Wenying,Patel Shilpen,Prins Sarah A.,Rava Richard,Ronaghi Neda,Sakarya Onur,Satya Ravi Vijaya,Schellenberger Jan,Scott Eric,Sehnert Amy J.,Shaknovich Rita,Shanmugam Avinash,Shashidhar K.C.,Shen Ling,Shenoy Archana,Shojaee Seyedmehdi,Singh Pranav,Steffen Kristan K.,Tang Susan,Toung Jonathan M.,Valouev Anton,Venn Oliver,Williams Richard T.,Wu Tony,Xu Hui H.,Yakym Christopher,Yang Xiao,Yecies Jessica,Yip Alexander S.,Youngren Jack,Yue Jeanne,Zhang Jingyang,Zhang Lily,Zhang Lori (Quan),Zhang Nan,Curtis Christina,Berry Donald A.

Funder

GRAIL, Inc

Princess Margaret Cancer Centre’s McCain GU BioBank

Francis Crick Institute

Cancer Research UK

UK Medical Research Council

Wellcome Trust

CRUK Lung Cancer Centre of Excellence

Rosetrees Trust

Breast Cancer Research Foundation

Publisher

Elsevier BV

Subject

Oncology,Hematology

Reference30 articles.

1. NIH National Cancer Insitute. Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov) SEER∗Stat Database: Incidence - SEER 18 Regs Research Data, Nov 2017 Sub (1973-2015) National Cancer Institute, DCCPS, Surveillance Research Program, released April 2018, based on the November 2017 submission. Statistic based on all invasive cancers, ages 50+ at diagnosis. [www.seer.cancer.gov].

2. Noone A, Howlander N, Krapcho M, et al., eds. SEER Cancer Statistics Review, 1975-2015, National Cancer Institute, software version 8.3.6. Bethesda. Available at: https://seer.cancer.gov/csr/1975_2015/.

3. Colorectal cancer screening: the role of psychological, social and background factors in decision-making process;Cossu;Clin Pract Epidemiol Ment Health,2018

4. Nationwide cross-sectional adherence to mammography screening guidelines: national behavioral risk factor surveillance system survey results;Narayan;Breast Cancer Res Treat,2017

5. Adherence to annual lung cancer screening within the Veterans Health Administration lung cancer screening demonstration project;Brasher;Chest,2018

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