Pro-oxidant vitamin C mechanistically exploits p66Shc/Rac1 GTPase pathway in inducing cytotoxicity

Author:

Mir Hilal Ahmad,Ali Roshia,Wani Zahoor Ahmad,Khanday Firdous Ahmad

Publisher

Elsevier BV

Subject

Molecular Biology,General Medicine,Biochemistry,Structural Biology

Reference50 articles.

1. Insights into the shc family of adaptor proteins;Ahmed;J. Mol. Signal.,2017

2. Signaling via shc family adapter proteins;Ravichandran;Oncogene,2001

3. Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor–MAP kinase–fos signalling pathway;Migliaccio;EMBO J.,1997

4. p46Shc inhibits thiolase and lipid oxidation in mitochondria;Tomilov;J. Biol. Chem.,2016

5. Structure-functional implications of longevity protein p66Shc in health and disease;Mir;Ageing Res. Rev.,2020

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