A novel Imidazo[1,2-a]pyridine derivative modulates active KRASG12D through off-like conformational shifts in switch-I and switch-II regions, mimicking inactive KRASG12D-Reference-Cited by-同舟云学术

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A novel Imidazo[1,2-a]pyridine derivative modulates active KRASG12D through off-like conformational shifts in switch-I and switch-II regions, mimicking inactive KRASG12D

Published:2024-06 Issue: Volume:270 Page:132477
ISSN:0141-8130
Container-title:International Journal of Biological Macromolecules
language:en
Short-container-title:International Journal of Biological Macromolecules

Author:

Ali Yasir,Khan Azmat Ali,Alanazi Amer M.,Fatima Shabeen,Kozmon Stanislav

Funder

Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR

King Saud University

Agentúra na Podporu Výskumu a Vývoja

Vedecká Grantová Agentúra MŠVVaŠ SR a SAV

Slovak Academy of Sciences

Publisher

Elsevier BV

Reference47 articles.

1. Drugging the undruggable RAS: Mission possible?;Cox;Nat. Rev. Drug Discov.,2014

2. Ras oncogenes in human cancer: a review;Bos;Cancer Res.,1989

3. A comprehensive survey of Ras mutations in cancer;Prior;Cancer Res.,2012

4. RAS proteins and their regulators in human disease;Simanshu;Cell,2017

5. Identification of the clinical development candidate MRTX849, a covalent KRASG12C inhibitor for the treatment of cancer;Fell;J. Med. Chem.,2020

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