Enhanced activity against a third-generation cephalosporin by destabilization of the active site of a class A beta-lactamase-Reference-Cited by-同舟云学术

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Enhanced activity against a third-generation cephalosporin by destabilization of the active site of a class A beta-lactamase

Published:2023-10 Issue: Volume:250 Page:126160
ISSN:0141-8130
Container-title:International Journal of Biological Macromolecules
language:en
Short-container-title:International Journal of Biological Macromolecules

Author:

Sun Jing,Chikunova Aleksandra,Boyle Aimee L.,Voskamp Patrick,Timmer Monika,Ubbink Marcellus

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

China Scholarship Council

Publisher

Elsevier BV

Subject

Molecular Biology,General Medicine,Biochemistry,Structural Biology

Reference76 articles.

1. Inactivation of antibiotics and the dissemination of resistance genes;Davies;Science,1994

2. The β-lactamase cycle: a tale of selective pressure and bacterial ingenuity;Matagne;Nat. Prod. Rep.,1999

3. Molecular mechanisms of antibiotic resistance revisited;Darby;Nat. Rev. Microbiol.,2022

4. Exploring the role of the Ω-loop in the evolution of ceftazidime resistance in the PenA β-lactamase from Burkholderia multivorans, an important cystic fibrosis pathogen;Papp-Wallace;Antimicrob. Agents Chemother.,2017

5. Natural evolution of TEM-1 β-lactamase: experimental reconstruction and clinical relevance;Salverda;FEMS Microbiol. Rev.,2010

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1. A low-barrier proton shared between two aspartates acts as a conformational switch that changes the substrate specificity of the β-lactamase BlaC;International Journal of Biological Macromolecules;2024-10

2. Sensitive quantification of fibroblast activation protein and high-throughput screening for inhibition by FDA-approved compounds;2024-06-26

3. Structural insight into the binding mode of cefotaxime and meropenem to TEM-1, SHV-1, KPC-2, and Amp-C type beta-lactamases;Cell Biochemistry and Biophysics;2024-05-10

4. Positive epistasis drives clavulanic acid resistance in double mutant libraries of BlaC β-lactamase;Communications Biology;2024-02-17

5. Drug Discovery in the Field of β-Lactams: An Academic Perspective;Antibiotics;2024-01-08

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