Poly-lysine supported cross-linked enzyme aggregates of penicillin G acylase and its application in synthesis of β-lactam antibiotics

Author:

Ye Jiajie,Li Anni,Chu Tianshu,Pan Xin,He Bingfang

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture

Publisher

Elsevier BV

Subject

Molecular Biology,General Medicine,Biochemistry,Structural Biology

Reference35 articles.

1. Current state and perspectives of penicillin G acylase-based biocatalyses;Helena;J. Appl. Microbiol. Biotechnol.,2014

2. ChemInform abstract: penicillin acylase in the industrial production of β-lactam antibiotics;Bruggink;J. J. ChemInform,2010

3. Towards biocatalytic synthesis of beta-lactam antibiotics;Wegman;J. Adv. Synth. Catal.,2001

4. Preparation of a novel nanobiocatalyst by immobilizing penicillin acylase onto magnetic nanocrystalline cellulose and its use for efficient synthesis of cefaclor;Huang;J. Chem. Eng. J.,2018

5. Improvement of enzyme activity, stability and selectivity via immobilization techniques;Mateo;J. Enzyme Microb. Technol.,2007

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