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Variability in the metabolism of proguanil to the active metabolite cycloguanil in healthy Kenyan adults

  • Published:1990-07 Issue:4 Volume:84 Page:492-495
  • ISSN:0035-9203
  • Container-title:Transactions of the Royal Society of Tropical Medicine and Hygiene
  • language:en
  • Short-container-title:Transactions of the Royal Society of Tropical Medicine and Hygiene

Author:

Watkins W.M.,Mberu E.K.,Nevill C.G.,Ward S.A.,Breckenridge A.M.,Koech D.K.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Public Health, Environmental and Occupational Health,General Medicine,Parasitology

Reference16 articles.

1. Metabolism of chlorguanide; a unique mixed function oxidase substrate;Armstrong,1972

2. Simultaneous measurement of proguanil and cycloguanil in human plasma by high performance liquid chromatography;Edstein;Journal of Chromatography,1986

3. Dihydrofolate reductase inhibitors;Ferone,1984

4. Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria;Hatton;Lancet,1986

5. A comparison of the pyrimethamine and cycloguanil sensitivities of the pre-erythrocytic and erythrocytic stages of drug-sensitive and -resistant strains of Plasmodium yoelii;Howells;Annals of Tropical Medicine and Parasitology,1985

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