Sustained treatment with an α5 GABA A receptor negative allosteric modulator delays excitatory circuit development while maintaining GABAergic neurotransmission

Author:

Nuwer Jessica L.ORCID,Brady Megan L.,Povysheva Nadya V.ORCID,Coyne Amanda,Jacob Tija C.

Publisher

Elsevier BV

Subject

Cellular and Molecular Neuroscience,Pharmacology

Reference90 articles.

1. NMDA receptor GluN2B (GluR epsilon 2/NR2B) subunit is crucial for channel function, postsynaptic macromolecular organization, and actin cytoskeleton at hippocampal CA3 synapses;Akashi;J. Neurosci.,2009

2. Native gamma-aminobutyric acid type A receptors from rat hippocampus, containing both alpha 1 and alpha 5 subunits, exhibit a single benzodiazepine binding site with alpha 5 pharmacological properties;Araujo;J. Pharmacol. Exp. Therapeut.,1999

3. Preclinical and clinical pharmacology of the GABAA receptor alpha5 subtype-selective inverse agonist alpha5IA;Atack;Pharmacol. Ther.,2010

4. GABAA receptor subtype-selective modulators. II. alpha5-selective inverse agonists for cognition enhancement;Atack;Curr. Top. Med. Chem.,2011

5. L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for alpha5-containing GABAA receptors;Atack;Neuropharmacology,2006

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