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Inhibition of neuronal Na+ currents by lacosamide: Differential binding affinity and kinetics to different inactivated states

  • Published:2020-11 Issue: Volume:179 Page:108266
  • ISSN:0028-3908
  • Container-title:Neuropharmacology
  • language:en
  • Short-container-title:Neuropharmacology

Author:

Peng Yi-Shuan,Wu Huang-Tzu,Lai Yi-Chen,Chen Jian-Lin,Yang Ya-Chin,Kuo Chung-Chin

Funder

Ministry of Science and Technology, Taiwan

Chang Gung Medical Foundation, Taiwan

Publisher

Elsevier BV

Subject

Cellular and Molecular Neuroscience,Pharmacology

Reference38 articles.

1. Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state;Bean;Proc. Natl. Acad. Sci. U.S.A.,1984

2. Lacosamide: a review of preclinical properties;Beyreuther;CNS Drug Rev.,2007

3. Molecular properties of brain sodium channels: an important target for anticonvulsant drugs;Catterall;Adv. Neurol.,1999

4. Structural basis for pharmacology of voltage-gated sodium and calcium channels;Catterall;Mol. Pharm.,2015

5. No pharmacokinetic interaction between lacosamide and valproic acid in healthy volunteers;Cawello;J. Clin. Pharmacol.,2012

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