Metformin attenuates cadmium-induced neuronal apoptosis in vitro via blocking ROS-dependent PP5/AMPK-JNK signaling pathway

Author:

Chen Xiaoling,Wu Wen,Gong Baoming,Hou Long,Dong Xiaoqing,Xu Chong,Zhao Rui,Yu Qianyun,Zhou Zhihan,Huang Shile,Chen Long

Funder

National Natural Science Foundation of China

National Institutes of Health

Project for the Priority Academic Program Development of Jiangsu Higher Education Institutions of China

American Cancer Society

Publisher

Elsevier BV

Subject

Cellular and Molecular Neuroscience,Pharmacology

Reference63 articles.

1. Cadmium-induced effects on bone in a population-based study of women;Akesson;Environ. Health Perspect.,2006

2. Metformin as a tool to target aging;Barzilai;Cell Metabol.,2016

3. Involvement of the synapse-specific zinc transporter ZnT3 in cadmium-induced hippocampal neurotoxicity;Ben Mimouna;J. Cell. Physiol.,2019

4. Metformin alleviated abeta-induced apoptosis via the suppression of JNK MAPK signaling pathway in cultured hippocampal neurons;Chen;BioMed Res. Int.,2016

5. Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5;Chen;Free Radic. Biol. Med.,2008

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