Gabapentin may inhibit synaptic transmission in the mouse spinal cord dorsal horn through a preferential block of P/Q-type Ca2+ channels

Author:

Bayer Katharina,Ahmadi Seifollah,Zeilhofer Hanns Ulrich

Publisher

Elsevier BV

Subject

Cellular and Molecular Neuroscience,Pharmacology

Reference42 articles.

1. Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells;Barclay;Journal of Neuroscience,2001

2. The anticonvulsant, antihyperalgesic agent gabapentin is an agonist at brain γ-aminobutyric acid type B receptors negatively coupled to voltage-dependent calcium channels;Bertrand;Journal of Pharmacology and Experimental Therapeutics,2001

3. The ducky mutation in Cacna2d2 results in altered Purkinje cell morphology and is associated with the expression of a truncated α2δ-2 protein with abnormal function;Brodbeck;Journal of Biological Chemistry,2002

4. 3-substituted GABA analogs with central nervous system activity: a review;Bryans;Medical Research Reviews,1999

5. Gabapentin as an antiepileptic drug in man;Crawford;Journal of Neurology Neurosurgery and Psychiatry,1987

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