HZ166, a novel GABAA receptor subtype-selective benzodiazepine site ligand, is antihyperalgesic in mouse models of inflammatory and neuropathic pain

Author:

Di Lio Alessandra,Benke Dietmar,Besson Marie,Desmeules Jules,Daali Youssef,Wang Zhi-jian,Edwankar Rahul,Cook James M.,Zeilhofer Hanns Ulrich

Publisher

Elsevier BV

Subject

Cellular and Molecular Neuroscience,Pharmacology

Reference31 articles.

1. MRK-409 (MK-0343), a GABAA receptor subtype-selective partial agonist, is a non-sedating anxiolytic in preclinical species but causes sedation in humans;Atack;J. Psychopharmacol.,2010

2. The benzodiazepine binding site of GABAA receptors as a target for the development of novel anxiolytics;Atack;Expert. Opin. Investig. Drugs.,2005

3. Reducing abuse liability of GABAA/benzodiazepine ligands via selective partial agonist efficacy at α1 and α2/3 subtypes;Ator;J. Pharmacol. Exp. Ther.,2010

4. The molecular architecture of GABA-A receptors;Barnard,2001

5. International Union of Pharmacology. XV. Subtypes of γ-aminobutyric acid A receptors: classification on the basis of subunit structure and receptor function;Barnard;Pharmacol. Rev.,1998

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