A single- and multiple-dose study to investigate the pharmacokinetics and pharmacodynamics of opicapone, a novel COMT inhibitor, in rat-Reference-Cited by-同舟云学术

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A single- and multiple-dose study to investigate the pharmacokinetics and pharmacodynamics of opicapone, a novel COMT inhibitor, in rat

Published:2017-10 Issue: Volume:125 Page:146-155
ISSN:0028-3908
Container-title:Neuropharmacology
language:en
Short-container-title:Neuropharmacology

Author:

Gonçalves Daniela,Alves Gilberto,Fortuna Ana,Bonifácio Maria João,Soares-da-Silva Patrício,Falcão Amílcar

Funder

Fundação para a Ciência e a Tecnologia

FSE (Fundo Social Europeu), União Europeia

BIAL – Portela & Ca S.A., Portugal

Publisher

Elsevier BV

Subject

Cellular and Molecular Neuroscience,Pharmacology

Reference38 articles.

1. Pharmacokinetics, pharmacodynamics and tolerability of opicapone, a novel catechol-O-methyltransferase inhibitor, in healthy subjects: prediction of slow enzyme-inhibitor complex dissociation of a short-living and very long-acting inhibitor;Almeida;Clin. Pharmacokinet.,2013

2. Species differences in pharmacokinetic and pharmacodynamic properties of nebicapone;Bonifácio;Biochem. Pharmacol.,2009

3. Catechol-O-methyltransferase and its inhibitors in Parkinson's disease;Bonifácio;CNS Drug Rev.,2007

4. Potential drug toxicity of nitrocatechol COMT inhibitors in HepaRG;Bonifácio;Toxicol. Lett.,2015

5. Brain and peripheral pharmacokinetics of levodopa in the cynomolgus monkey following administration of opicapone, a third generation nitrocatechol COMT inhibitor;Bonifácio;Neuropharmacology,2014

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Developmental and behavioral toxicity assessment of opicapone in zebrafish embryos;Ecotoxicology and Environmental Safety;2023-01

2. Parkinson's disease: Current drug therapy and unraveling the prospects of nanoparticles;Journal of Drug Delivery Science and Technology;2020-08

3. The preclinical discovery and development of opicapone for the treatment of Parkinson’s disease;Expert Opinion on Drug Discovery;2020-05-26

4. Neurological and psychiatric management using COMT inhibitors: A review;Bioorganic Chemistry;2020-01

5. Inhibition of catechol-O-methyltransferase in the cynomolgus monkey by opicapone after acute and repeated administration;Neuropharmacology;2018-12

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