Role of membrane cholesterol in differential sensitivity of muscarinic receptor subtypes to persistently bound xanomeline

Author:

Randáková Alena,Dolejší Eva,Rudajev Vladimír,Zimčík Pavel,Doležal Vladimír,El-Fakahany Esam E.,Jakubík Jan

Funder

Czech Academy of Sciences

Grant Agency of the Czech Republic

Publisher

Elsevier BV

Subject

Cellular and Molecular Neuroscience,Pharmacology

Reference45 articles.

1. Integrated methods for the construction of three dimensional models and computational probing of structure function relations in G protein-coupled receptors;Ballesteros,1995

2. Effect of the lipid environment on the differential affinity of purified cerebral and atrial muscarinic acetylcholine receptors for pirenzepine;Berstein;Mol. Pharmacol.,1989

3. M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss;Bradley;J. Clin. Invest.,2016

4. Xanomeline compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects;Bymaster;Brain Res.,1998

5. On the unique binding and activating properties of xanomeline at the M1 muscarinic acetylcholine receptor;Christopoulos;Mol. Pharmacol.,1998

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