Mechanism based neurotoxicity of mGlu5 positive allosteric modulators – Development challenges for a promising novel antipsychotic target

Author:

Parmentier-Batteur Sophie,Hutson Peter H.,Menzel Karsten,Uslaner Jason M.,Mattson Britta A.,O'Brien Julie A.,Magliaro Brian C.,Forest Thomas,Stump Craig A.,Tynebor Robert M.,Anthony Neville J.,Tucker Thomas J.,Zhang Xu-Fang,Gomez Robert,Huszar Sarah L.,Lambeng Nathalie,Fauré H.,Le Poul Emannuel,Poli Sonia,Rosahl Thomas W.,Rocher Jean-Philippe,Hargreaves Richard,Williams Theresa M.

Publisher

Elsevier BV

Subject

Cellular and Molecular Neuroscience,Pharmacology

Reference54 articles.

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3. Allosteric enhancement of metabotropic glutamate receptor 5 function promotes spatial memory;Balschun;Neuroscience,2006

4. Mechanisms of synaptic depression triggered by metabotropic glutamate receptors;Bellone;Cell. Mol. Life Sci.,2008

5. Seizures and neuronal damage induced in the rat by activation of group I metabotropic glutamate receptors with their selective agonist 3,5-dihydroxyphenylglycine;Camon;J. Neurosci. Res.,1998

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