In vitro inhibition of β-haematin formation, DNA interactions, antiplasmodial activity, and cytotoxicity of synthetic neocryptolepine derivatives

Author:

Van Miert Sabine,Jonckers Tim,Cimanga Kanyanga,Maes Louis,Maes Bert,Lemière Guy,Dommisse Roger,Vlietinck Arnold,Pieters Luc

Publisher

Elsevier BV

Subject

Immunology,General Medicine,Parasitology,Infectious Diseases

Reference23 articles.

1. New synthesis of benzo-δ-carbolines, cryptolepines, and their salts: in vitro cytotoxic, antiplasmodial, and antitrypanosomal activities of δ-carbolines, benzo-δ-carbolines, and cryptolepines;Arzel;Journal of Medicinal Chemistry,2001

2. DNA intercalation, topoisomerase II inhibition and cytotoxic activity of the plant alkaloid neocryptolepine;Bailly;Anti-Cancer Drug Design,2000

3. Ethnobotanical-directed discovery of the antihyperglycemic properties of cryptolepine: its isolation from Cryptolepis sanguinolenta, synthesis, and in vitro and in vivo activities;Bierer;Journal of Medicinal Chemistry,1998

4. Critical evaluation of the DNA–methylgreen assay: application to some indole alkaloids;Bonjean;Phytotherapy Research,1996

5. The DNA intercalating alkaloid cryptolepine interferes with topoisomerase II and inhibits primarily DNA synthesis in B16 melanoma cells;Bonjean;Biochemistry,1998

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