Schistosoma japonicum scFv-IL18 fusion DNA ameliorates hepatic fibrosis in schistosomiasis-infected mice via improving local concentration of IL-18 in liver

Author:

Tian Zhi,Wang Xi-ya,Zhou Yun-fei,Feng Qi-mei,Zhang Shu-ju,Yin Tie-qiu,Xu Shao-rui,Xia Ying-ding,Xu Jin,Jin Jing,Wang Shi-ping

Funder

National Scientific and Technological Support Projects

Natural Science Foundation of Hunan Province

Key Laboratory of Immune and Control Schistosomiasis and Key Subject Development Special Program of Hunan Province

Publisher

Elsevier BV

Subject

Immunology,General Medicine,Parasitology,Infectious Diseases

Reference24 articles.

1. Variation of hepatic fibrosis and granuloma size among mouse strains infected with Schistosoma mansoni;Cheever;Am. J. Trop. Med. Hyg.,1987

2. Gao, D.M., 2010. Study on the Immuno-Target of Specific Single Chain Antibody against SIEA26-28 ku and Its Efficacy as Therapeutic Vaccine against schistosomiasis. Central South University: 29–46.(Ph.D. Thesis.)

3. Schistosoma japonicum: screening of cercariae cDNA library by specific single-chain antibody against SIEA26-28 ku and immunization experiment of the recombinant plasmids containing the selected genes;Gao;Parasitol. Res.,2010

4. Construction screening and application of single-chain Fv antibody library against immature egg of Schistosoma japonicum;He;Prog. Biochem. Biophys.,2008

5. IL-18 downregulates collagen production in human dermal fibroblasts via the ERK pathway;Kim;J. Invest. Dermatol.,2010

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