Relative hydrophobicity and lipophilicity of drugs measured by aqueous two-phase partitioning, octanol-buffer partitioning and HPLC. A simple model for predicting blood–brain distribution-Reference-Cited by-同舟云学术

Relative hydrophobicity and lipophilicity of drugs measured by aqueous two-phase partitioning, octanol-buffer partitioning and HPLC. A simple model for predicting blood–brain distribution

Published:2003-04 Issue:4 Volume:38 Page:391-396
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Gulyaeva Nellie,Zaslavsky Alexander,Lechner Pamela,Chlenov Michael,McConnell Oliver,Chait Arnon,Kipnis Victor,Zaslavsky Boris

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference26 articles.

1. On the Partition of Ampholytes: Application to Blood–Brain Distribution

2. Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 2. Prediction of blood–brain barrier penetration

3. Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists

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