Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Author:

Al-Shahi Salman Rustam,Minks David P,Mitra Dipayan,Rodrigues Mark A,Bhatnagar Priya,du Plessis Johann C,Joshi Yogish,Dennis Martin S,Murray Gordon D,Newby David E,Sandercock Peter A G,Sprigg Nikola,Stephen Jacqueline,Sudlow Cathie L M,Werring David J,Whiteley William N,Wardlaw Joanna M,White Philip M,Baigent Colin,Lasserson Daniel,Sullivan Frank,Carrie Johanna,Rojas Javier,Amoils Shannon,Bamford John,Armitage Jane,Rinkel Gabriel,Lowe Gordon,Emberson Jonathan,Innes Karen,Dinsmore Lynn,Drever Jonathan,Williams Carol,Perry David,McGill Connor,Buchanan David,Walker Allan,Hutchison Aidan,Matthews Christopher,Fraser Ruth,McGrath Aileen,Deary Ann,Anderson Rosemary,Walker Pauli,Hansen Christian,Parker Richard,Rodriguez Aryelly,Macleod Malcolm,Gattringer Thomas,Palmer Jeb,Sakka Eleni,Adil-Smith Jennifer,Minks David,Mitra Dipayan,Bhatnagar Priya,du Plessis Johannes,Joshi Yogish,Lerpiniere Christine,O'Brien Richard,Burgess Seona,Mead Gillian,Paulton Ruth,Doubal Fergus,McCormick Katrina,Hunter Neil,Taylor Pat,Parakramawansha Ruwan,Perry Jack,Blair Gordon,MacRaild Allan,Parry-Jones Adrian,Johnes Mary,Lee Stephanie,Shaw Kelly Marie,Burger Ilse,Punter Martin,Ingham Andrea,Perez Jane,Naing Zin,Morell Jordi,Marsden Tracy,Hall Andrea,Marshall Sally,Harrison Louise,Jarapa Rowilson,Wood Edith,O'Loughlin Victoria,Cohen David,Davies Silvie,Njoku Kelechi,Mpelembue Mushiya,Burgess Laura,Licenik Radim,Ngwako Mmua,Nisar Nabeela,Niranchanan Rangah,Roganova Tatjana,Bathula Rajaram,Devine Joseph,David Anette,Oshodi Anne,Guo Fenglin,Owoyele Emmanuelle,Sukdeo Varthi,Ballantine Robert,Abbdul-saheb Mudhar,Chamberlain Angela,Chandrakumar Aberami,Poku Philip,Harkness Kirsty,Blank Catrin,Richards Emma,Ali Ali,Kibutu Faith,Balitska Olesia,Birchall Kathryn,Bayliss Pauline,Doyle Clare,Stocks Kathy,Majis Arshad,Howe Jo,Kamara Christine,Barron Luke,Maatouk Ahmad,Lindert Ralf,Dakin Katy,Redgrave Jessica,Bhaskaran Biju,Salih Isam,Kelly Debs,Szabo Susan,Tomlin Dawn,Bearne Helen,Buxton Jean,Fitzell Pauline,Ayres Georgina,Saulat Afaq,Horan Kathleen,Garfield-Smith Joanne,Bhakri Harbens,Guyler Paul,Sinha Devesh,Loganathan Thayalini,Siddiqui Amber,Siddiqui Anwer,Coward Lucy,Kunhunny Swapna,Tysoe Sharon,Orath Prabakaran Rajalakshmi,Kelavkar Shyam,Rashmi Sindhu,Ngo David,Ng Kheng Xiong,Menon Nisha,Shah Sweni,Barber Mark,Esson Derek,Brodie Fiona,Anjum Talat,Wani Mushtaq,Krishnan Manju,Quinn Leanne,Spencer Jayne,Jones Terry,Thompson-Jones Helen,Dacey Lynne,Chenna Srikanth,Storton Sharon,Thomas Sarah,Beaty Teresa,Treadwell Shelley,Davies Caroline,Tucker Susan,Connor Lynda,Slade Peter,Gainard Glyn,Muddegowda Girish,Sanyal Ranjan,Remegoso Alda,Abano Nenette,Causley Chelsea,Carpio Racquel,Stevens Stephanie,Butler Adrian,Varquez Resti,Denic Hayley,Alipio Francis,Moores Andrew,Barry Adrian,Maguire Holly,Grocott Jeanette,Finney Kay,Lyjko Sue,Roffe Christine,Hiden Joanne,Ferdinand Phillip,Cvoro Vera,Ullah Khalil,Chapman Nicola,Couser Mandy,Pound Susan,McCormick Katrina,Mcauley Sean,Raghunathan Senthil,Shelton Faye,Hedstrom Amanda,Godfrey Margi,Havard Diane,Buck Amanda,Krishnan Kailash,Gilzeane Nicola,Roffe Jack,Clarke Judith,Whittamore Katherine,Sheikh Saima,Sprigg Nikola,Keshvara Rekha,Jordan Carla,Jackson Benjamin,Wilkes Gwendoline,Appleton Jason,Law Zhe,Matias Oliver,Vasileiadis Evangelos,Mason Cathy,Parry Anthea,Landers Geraldine,Holden Melinda,Aweid Basaam,Rashed Khalid,Balian Linda,Vickers Carinna,Keeling Elizabeth,Board Sarah,Allison Joanna,Buckley Clare,Williams-Yesson Barbara,Board Joanne,Pitt-Kerby Tressy,Tanate Alfonso,Wood Diane,Kini Manohar,Chadha Dinesh,Walstow Deborah,Fong Rosanna,Luder Robert,Adesina Tolu,Gallagher Jill,Bridger Hayley,Murali Elodie,Bhargava Maneesh,van Someren Chloe,Harrington Frances,Mate Abhijit,James Ali,Courtauld Gillian,Schofield Christine,Adie Katja,Lucas Linda,Bond Kirsty,Maund Bev,Ellis Sam,Mudd Paul,James Martin,Keenan Samantha,Bowring Angela,Cageao Julie,Kingwell Hayley,Roughan Caroline,Hemsley Anthony,Sword Jane,Strain David,Miller Keniesha,Goff Anita,Gupwell Karin,Thorpe Kevin,Emsley Hedley,Punekar Shuja,McLoughlin Alison,Sultan Sulaiman,Gregory Bindu,Raj Sonia,Doyle Donna,Muir Keith,Smith Wilma,Welch Angela,Moreton Fiona,Cheripelli Bharath Kumar,El Tawil Salwa,Kalladka Dheeraj,Huang Xuya,Day Nicola,Ramachandran Sankaranarayanan,Crosbie Caroline,Elliot Jennifer,Rudd Tony,Marks Katherine,Bhalla Ajay,Birns Jonathan,Kullane Sagal,Weir Nic,Allen Christopher,Pressly Vanessa,Crawford Pam,Battersby-Wood Emma,Blades Alex,Egerton Shuna,Walters Ashleigh,Evans Sue,Marigold James Richard,Smith Fiona,Howard Gabriella,Gartrell Imogen,Smith Simon,Creeden Robyn,Cox Chloe,Boxall Cherish,Hewitt Jonathan,Nott Claire,Sarah Procter,Whiteman Jessica,Buckle Steve,Wallace Rebecca,Mardania Rina,Gray Jane,Triscott Claire,Nair Anand,Greig Jill,Rana Pratap,Robinson Matthew,Alam Mohammad Irfan,Werring David,Wilson Duncan,Watchurst Caroline,Brezitski Maria,Crook Luci,Jones Ifan,Banaras Azra,Patel Krishna,Erande Renuka,Hogan Caroline,Hostettler Isabel,Ashton Amy,Feerick Shez,Francia Nina,Oji Nnebuife,Elliott Emma,Al-Mayhani Talal,Dennis Martin,Sudlow Cathie,Whiteley William,Lerpiniere Christine,Al-Shahi Salman Rustam,Fraser Ruth,Dutta Dipankar,Brown Pauline,Ward Deborah,Davis Fiona,Turfrey Jennifer,Hughes Chloe,Collins Kayleigh,Bakawala Rehana,O'Connell Susan,Glass Jon,Broughton David,Tryambake Dinesh,Dixon Lynn,Chapman Kath,Young Andrew,Bergin Adrian,Sigsworth Andrew,Manoj Aravind,Fletcher Glyn,Lopez Paula,Cox Penelope,Wilkinson Mark,Fitzsimmons Paul,Sharma Nikhil,Choulerton James,Button Denise,Dow Lindsey,Gbadamoshi Lukuman,Avis Joanne,Madigan Barbara,McCann Stephanie,Shaw Louise,Howcroft Deborah,Lucas Suzanne,Stone Andrew,Cluckie Gillian,Lovelock Caroline,Clarke Brian,Chopra Neha,Clarke Natasha,Patel Bhavini,Kennedy Kate,Williams Rebecca,Blight Adrian,O'Reilly Joanna,Orefo Chukwuka,Dayal Nilofer,Ghatala Rita,Adedoyin Temi,Watson Fran,Trippier Sarah,Choy Lillian,Moynihan Barry,Khan Usman,Jones Val,Jeyaraj Naomi,Kerin Lourda,Thavanesan Kamy,Tiwari Divya,Cox Chantel,Ljubez Anja,Tucker Laura,Iqbal Arshi,Bagnall Caroline,Keltos Marketa,Roberts Josh,Jupp Becky,Ovington Catherine,Rogers Emily,David Owen,Bell Jo,Longland Barbara,Hann Gail,Cooper Martin,Nasar Mohammad,Rajapakse Anoja,Wynter Inez,Anwar Ijaz,Skinner Helen,Nozedar Tarn,McArdle Damian,Kumar Balakrishna,Crawford Susan,Annamalai Arunkumar,Ramshaw Alex,Holmes Clare,Caine Sarah,Osborn Mairead,Dodd Emily,Murphy Peter,Devitt Nicola,Baker Pauline,Steele Amy,Guthrie Lucy Belle,Clarke Samantha,Hassan Ahamad,Waugh Dean,Veraque Emelda,Makawa Linetty,Kambafwile Mary,Randall Marc,Papavasileiou Vasileios,Cullen Claire,Peters Jenny,Thant Hlaing,Ingram Tanya,Zoe Mellor,Durairaj Ramesh,Harrison Melanie,Stevenson Sarah,Shackcloth Daniela,Ewing Jordan,Sutton Victoria,McCarron Mark,McKee Jacqueline,Doherty Mandy,McVerry Ferghal,Blair Caroline,MacLeod Mary,Irvine Janice,Gow Heather,Furnace Jacqueline,Joyson Anu,Jagpal Baljit,Ross Sarah,Klaasen Katrina,Nelson Sandra,Clarke Rebecca,Crouch Nichola,MacLennan Beverly,Taylor Vicky,Epstein Daniel,Jones Ifan,Shukla Avani,Krishnamurthy Vinodh,Nicholas Paul,Qureshi Sammie,Webber Adam,Penge Justin,Ramadan Hawraman,Maguire Stuart,Patterson Chris,Bellfield Ruth,Hairsine Brigid,Stewart Kelvin,Hooley Michaela,Quinn Outi,Richard Bella,Moseley Sally,Nott Claire,Buckle Steve,Sarah Procter,Whiteman Jessica,Edwards Mandy,Lawson Heidi,Wallace Rebecca,Triscott Claire,Tayler Michelle,Pai Yogish,Dhakal Mahesh,Esisi Bernard,Dima Sofia,Smith Gemma Marie,Garside Mark,Naeem Muhammad,Baliga Vidya,Rogers Gill,Brown Ellen,Bruce David,Hayman Rachel,Clayton Susan,Gamble Ed,Grue Rebecca,Charles Bethan,Hague Adam,Blane Sujata,Lambert Caroline,Chaudhry Afnan,Harrison Thomas,Saastamoinen Kari,Hove Dionne,Howaniec Laura,Grimwood Gemma,Redjep Ozlem,Humphries Fiona,Argandona Lucia,Cuenoud Larissa,Erumere Esther,Amlani Sageet,Auld Grace,Salek-Haddadi Afraim,Schulz Ursula,Kennedy James,Ford Gary,Mathieson Philip,Reckless Ian,Teal Rachel,Lenti Giulia,Harston George,O'Brien Eoin,Mcgee Joanne,Mitchell Jennifer,Amis Elaine,Handley Dominic,Kelly Siobhan,Zachariah George,Francis Jobbin,Crisp Sarah,Sesay Juliana,Finlay Sarah,Hayhoe Helen,Hannon Niamh,Hughes Tom,Morse Bethan,De Berker Henry,Tallantyre Emma,Osman Ahmed,White Susan,Schwarz Stefan,Jelley Benjamin,Yadava Rajendra,Azhar Khalid,Reddan Julie,Sangombe Mirriam,Stafford Samantha,Fotherby Ken,Morgan Debbie,Baig Farrukh,Jennings-Preece Karla,Butler Donna,Ahmad Nasar,Willberry Angela,Stevens Angela,Rai Baljinder,Siddegowda Prasad,Howard Peter,Saulat Afaq,Hyatt Lisa,Dobson Tracey,Jarrett David,Ponnambath Suheil,Tandy Jane,Harrington-Davies Yasmin,Butler Rebecca,James Claire,Valentine Stacey,Suttling Anne,Langhorne Peter,Kerr Gillian,Wright Fiona,Graham Ruth,McAlpine Christine,Iqbal Mohammad Shahzad,Humphreys Louise,Pasco Kath,Balazikova Olga,Nasim Ashraf,Peixoto Cassilda,Gallagher Louise,Shahmehri Shahrzad,Ghosh Sandip,Barrie Elizabeth,Gilmour Danielle,Henry Margo,Webb Tom,Cowie Linda,Rudenko Hannah,McDonald Shanni,Schumacher Natasha,Walker Susannah,Cosier Tracey,Verrion Anna,Beranova Eva,Thomson Audrey,Venter Marius,Kar Arindam,Mashate Sheila,Harvey Kirsten,Gardener Léjeune,Nguyen Vinh,Halse Omid,Geraghty Olivia,Hazel Beth,Wilding Peter,Tilley Victoria,Esisi Bernard,Cassidy Tim,McClelland Beverley,Bokhari Maria,England Timothy,Hedstrom Amanda,Maddula Mohana,Donnelly Richard,Findlay Paul,Macaden Ashish,Shread Ian,Barr Charlotte,Mohd Nor Azlisham,Brown Claire,Persad Nicola,Eglinton Charlotte,Weinling Marie,Hyams Benjamin,Shah Alex,Baker John,Byrne Anthony,McGhee Caroline,Smart Amanda,Copeland Claire,Carpenter Michael,Walker Marion,Davey Richard,Needle Ann,Fathima Razik,Bateman Gavin,Datta Prabal,Stanners Andrew,Jackson Linda,Ball Julie,Davis Michelle,Atkinson Natalie,Fawcett Michelle,Thompson Teresa,Guy Helen,Hogg Valerie,Hays Carole,Woodward Stephen,Haque Mohammad,Hakim Eluzai,Symonds Stuart,Maanoosi Mehran,Herman Jane,Black Toby,Miriam Skelton,Clarke Caroline,Anthony Alpha,Tribbeck Michele,Cronin Julie,Mead Denise,Fennelly Ruth,McIlmoyle James,Dickinson Christina,Jeffs Carol,Anwar Sajjad,Howard Joanne,Jones Kirsty,Dhar Saikat,Clay Caroline,Siddiq Muhammad,Ivatts Simone,Baird Yolanda,Sally Moore,Amey Isobel,Newton Sophie,Clayton-Evans Lisa,Chadbourn Indra,Rayessa Rayessa,Naylor Charde,Rodgers Alicia,Wilson Lisa,Wilson Sarah,Clarkson Emma,Davies Ruth,Owings Paula,Sangster Graeme,Gott Valerie,Little Victoria,Weir Pauline,Cherian Suja,Jose Deepa,Moroney Helen,Downham Susan,Dodd Angela,Vettimootal Johnson Venetia,Codd Laura,Robinson Naomi,Ahmed Ashraf,Albazzaz Mo,Johnson Sharon,Denniss Carol,Cunningham Mishell,Zahoor Tajammal,Webster Timothy,Leason Sandra,Haider Syed,Chatterjee Kausic,Nallasivan Arumugam,Perkins Charlotte,Seagrave Samantha,Jenkins Colin,Price Fiona,Hughes Claire,Mercer Lily,Hussain Malik,Brown Sarah,Harvey Miriam,Homan Jane,Khan Mohammad,Whiting Robert,Foote Leanne,Hunt Nicholas,Durman Helen,Brotherton Lucy,Foot Jayne,Pawley Corinne,Foster Eliza,Whitcher Alison,Metcalf Kneale,Jagger Jenny,McDonald Susan,Waterfield Kelly,Sutton Patrick,Shinh Naval,Anversha Ajmal,Ravenhill Garth,Greenwood Richard,Saada Janak,Wiltshire Alison,Perfitt Rebekah,Andole Sreeman,Gadapa Naveen,Dunne Karen,Krommyda Magdalini,Burssens Evelyne,King Sam,Plewa Catherine,Smyth Nigel,Wilson Jenny,Giallombardo Elio,Eglinton Charlotte,Sykes Lucy,Kumar Pradeep,Barker James,Huggett Isabel,Dunn Linda,Culmsee Charlotte,Thomas Philip,Myint Min,O'Brien Richard,Brew Helen,Majmudar Nikhil,OConnell Janice,Bunea George,Fox Charlotte,Gulliver Diane,Smith Andrew,Mokoena Betty,Sattar Naweed,Krishnamurthy Ramesh,Osborne Emily,Wilson David,Wroath Belinda,Dynan Kevin,Power Michael,Thompson Susan,Adell Victoria,Orugun Enoch,Poultney Una,Glover Rachel,Crowther Hannah,Thornthwaite Sarah,Wiggam Ivan,Wallace Aine,Kerr Enda,Fulton Ailsa,Hunter Annemarie,Tauro Suzanne,Cuddy Sarah,Mangion David,Hardwick Anne,Markova Skarlet,Lawrence Tara,Constantin Carmen,Fletcher Jo,Thomas Isobel,Pettitt Kerry,Sekaran Lakshmanan,Tate Margaret,Bharaj Kiranjit,Simon Rohan,Justin Frances,Sethuraman Sakthivel,Phiri Duke,Mohammed Niaz,Chauhan Meena,Elfandi Khaled,Khan Uzma,Stafford Samantha,Reddan Julie,Eveson David,Mistri Amit,Manning Lisa,Khan Shagufta,Patel Champa,Moqsith Mohammed,Sattar Saira,Lam Man Yee,Musarrat Kashif,Stephens Claire,Kalathil Latheef,Miller Richard,Salehin Maqsud,Gautam Nikki,Bailey Duncan,Amor Kelly,Meir Julie,Nicolson Anne,Imam Javed,Wood Lisa,White Julie,Sajid Mahmud,Ghaly George,Ball Margaret,Gascoyne Rachel,Proeschel Harald,Sharpe Simon,Horton Sarah,Beaves Emily,Jones Stephanie,Yip Brigitte,Bell Murdina,MacLiver Linda,MacInnes Brian,Esson Derek,Sims Don,Hurley Jennifer,Willmot Mark,Sutton Claire,Littleton Edward,Maiden Susan,Jones Rachael,Cunningham James,Green Carole,Bates Michelle,Shekhar Raj,Waterfield Kelly,Gilham Ellie,Ahmed Iman,Crown Rachel,Fuller Tracy,Goorah Neetish,Bell Angela,Kelly Christine,Singh Arun,Walford Jamie,Tomlinson Benjamin,Patel Farzana,Duberley Stephen,Kane Ingrid,Rajkumar Chakravarthi,Gaylard Jane,Breeds Joanna,Gainsborough Nicola,Pitt-Ford Alexandra,Barbon Emma,Latter Laura,Thompson Philip,Hervey Simon,Krishnamoorthy Shrivakumar,Vassallo Joseph,Walter Deborah,Cochrane Helen,Srinivasan Meena,Campbell Robert,Donaldson Denise,Motherwell Nichola,Hurford Frances,Mukherjee Indranil,Kenton Antony,Nyabadza Sheila,Martin Irene,Hunt Benjamin,Hassan Hardi,O'Toole Sarah,Dallol Bander,Putterill Janet,Jha Ratneshwari,Gallifent Rachel,Kakar Puneet,Pusalkar Aparna,Chan kelly,Dangri Puneet,Beadle Hannah,Cook Angela,Crabtree Karen,Subramonian Santhosh,Owusu-Agyei Peter,Temple Natalie,Butterworth-Cowin Nicola,Ragab Suzanne,Knops Kerstin,Jinks Emma,Dickson Christine,Gleave Laura,Dube Judith,Leggett Jacqui,Garcia Tatiana,Ispoglou Sissy,Evans Rachel,Ankolekar Sandeep,Hayes Anne,Ni Hlaing,Rahman Bithi,Milligan Josette,Graham Carol,Jose Josin,Keegan Breffni,Doherty Mandy,Kelly Jim,Blair Caroline,Dewar Richard,White James,Thomas Kelly

Funder

British Heart Foundation

British Heart Foundation for funding the trial with a Special Project Grant

Publisher

Elsevier BV

Subject

Neurology (clinical)

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