A novel assay for cytosolic 3-hydroxy-3-methylglutaryl-coenzyme A synthase activity using reversed-phase ion-pair chromatography: demonstration that Lifibrol (K12.148) modulates the enzyme activity.

Author:

Scharnagl H,März W,Schliack M,Löser R,Gross W

Publisher

Elsevier BV

Subject

Cell Biology,Endocrinology,Biochemistry

Reference23 articles.

1. HMG-CoA reductase inhibitors for treatment of hypercholesterolemia. N Engl;Grundy;J Med.,1988

2. Influence of pravastatin, a specific inhibitor of HMG-CoA reductase, on hepatic metabolism of cholesterol;Reihner;N Engl. JMed.,1990

3. Intracellular localization of the 3- hydroxy-3-methylglutaryl coenzyme A cycle enzymes in liver. Separate cytoplasmic and mitochondrial 3-hydroxy- 3-methylglutaryl coenzyme A generating systems for cho?lesterogenesis and ketogenesis;Clinkenbeard;,J Biol. Chern.,1975

4. Cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase from liver. Purification, properties, and role in cholesterol synthesis;Clinkenbeard;J Biol. Chern.,1975

5. Molecular and catalytic properties of mitochondrial (ketogenic) 3-hydroxy-3-methylglutaryl coenzyme A synthase of liver;Reed;J. Biol. Chern,1975

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