Epitope analysis of the thyrotropin receptor, 19971Note: All residue numbers are counted from the methionine start site. All TSHR peptides are designated by the corresponding N- and C-terminal residue numbers.1

Author:

Kosugi Shinji,Sugawa Hideo,Mori Toru

Publisher

Elsevier BV

Subject

Endocrinology,Molecular Biology,Biochemistry

Reference58 articles.

1. Kosugi, S., Ban, T., Akamizu, T. and Kohn, L.D. (1992) Identification of separate determinants on the thyrotropin receptor reactive with Graves' thyroid-stimulating antibodies and with thyroid-stimulating blocking antibodies in idiopathic myxedema: these determinants have no homologous sequence on gonadotropin receptors. Mol. Endocrinol. 6, 168–180.

2. Kosugi, S., Ban, T. and Kohn, L.D. (1993) Identification of thyroid stimulating antibody-specific interaction sites in the N-terminal region of the thyrotropin receptor. Mol. Endocrinol. 7, 114–130.

3. Kosugi, S., Ban, T., Akamizu, T., Valente, W. and Kohn, L.D. (1993) Use of thyrotropin receptor (TSHR) mutants to detect stimulating TSHR antibodies in hypothyroid patients with idiopathic myxedema, who have blocking TSHR antibodies. J. Clin. Endocrinol. Metab. 77, 19–24.

4. Kosugi, S., Ban, T., Akamizu T. and Kohn, L.D. (1991) Site-directed mutagenesis of a portion of the extracellular domain of the rat thyrotropin receptor important in autoimmune thyroid disease and nonhomologous with gonadotropin receptors: relationship of functional and immunogenic domains. J. Biol. Chem. 266, 19413–19418.

5. Kosugi, S., Ban, T., Akamizu, T. and Kohn, L.D. (1991) Further characterization of a high affinity thyrotropin binding site on the rat thyrotropin receptor which is an epitope for blocking antibodies from idiopathic myxedema patients but not thyroid stimulating antibodies from Graves' patients. Biochem. Biophys. Res. Commun. 180, 1118–1124.

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