Urotensin-II receptor blockade with SB-611812 attenuates cardiac remodeling in experimental ischemic heart disease

Author:

Bousette Nicolas,Pottinger Julia,Ramli Wisam,Ohlstein Eliot H.,Dhanak Dashyant,Douglas Stephen A.,Giaid Adel

Publisher

Elsevier BV

Subject

Cellular and Molecular Neuroscience,Endocrinology,Physiology,Biochemistry

Reference21 articles.

1. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14;Ames;Nature,1999

2. Urotensin-II blockade with SB-611812 attenuates cardiac dysfunction in a rat modal of coronary artery ligation;Bousette;J Mol Cell Cardiol,2006

3. Dhanak D, Knight SD. Sulfonamide derivative urotensin-II receptor antagonists, preparation, pharmaceutical compositions, and therapeutic use. PCT Int Appl WO 2,001,045,694 2001.

4. Congestive heart failure and expression of myocardial urotensin II;Douglas;Lancet,2002

5. Molecular and pharmacological characterization of genes encoding urotensin-II peptides and their cognate G-protein-coupled receptors from the mouse and monkey;Elshourbagy;Br J Pharmacol,2002

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