Impact of age on in vitro metabolism of clopidogrel: a potential explanation for high on-treatment platelet reactivity in the elderly?
Author:
Funder
Centre Hospitalier Universitaire de Rennes
Publisher
Elsevier BV
Subject
Hematology
Reference26 articles.
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2. Cytochromes P450 catalyze both steps of the major pathway of clopidogrel bioactivation, whereas paraoxonase catalyzes the formation of a minor thiol metabolite isomer;Dansette;Chem Res Toxicol,2012
3. Structure and stereochemistry of the active metabolite of clopidogrel;Pereillo;Drug Metab Dispos,2002
4. Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogrel, and prasugrel in humans;Farid;J Clin Pharmacol,2010
5. Metabolic oxidative cleavage of thioesters: evidence for the formation of sulfenic acid intermediates in the bioactivation of the antithrombotic prodrugs ticlopidine and clopidogrel;Dansette;Chem Res Toxicol,2009
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