Synthesis of BODIPY dyes through postfunctionalization of the boron dipyrromethene core

Author:

Boens Noël,Verbelen Bram,Ortiz María J.,Jiao Lijuan,Dehaen Wim

Funder

KU Leuven

MINECO

National Nature Science Foundation of China

Nature Science Foundation of Anhui Province

Publisher

Elsevier BV

Subject

Materials Chemistry,Physical and Theoretical Chemistry,Inorganic Chemistry

Reference568 articles.

1. Molecular Fluorescence;Valeur,2002

2. Principles of Fluorescence Spectroscopy;Lakowicz,2006

3. Handbook of Fluorescence Spectroscopy and Imaging;Sauer,2011

4. Glossary of terms used in photochemistry, 3rd edition (IUPAC Recommendations 2006)

5. The name BODIPY, acronym for boron dipyrromethene (or boron dipyrrin), was coined by Richard P. Haugland (1943–2016) to describe the class of fluorophores based on the 4-bora-3a,4a-diaza-s-indacene platform, and used as early as December 1989 (in BioProbes 10, the newsletter of Molecular Probes, Inc.). The trademark BODIPY® was filed on May 29, 1990 by Molecular Probes, Inc. and is maintained as a registered trademark by the company with the U.S. Patent and Trademark Office since October 8, 1991. In 1975, Richard P. Haugland and his wife Rosaria P. Haugland cofounded Molecular Probes in Eugene, OR (USA). The corporation was bought in 2003 by Invitrogen, which was sold to Thermo Fisher Scientific in 2013. Beginning in 1986, Hee C. Kang and Richard P. Haugland of Molecular Probes set out to synthesize fluorescent, reactive forms of BODIPY molecules for biomolecule derivatization. Their first U.S. patent (4,774,339) on chemically reactive BODIPY dyes was issued in September 1988 (reference 74). Since then, numerous patented BODIPY derivatives have been made commercially available to the scientific community. For more information about BODIPY fluorophores and their applications, refer to The Molecular Probes® Handbook. A Guide to Fluorescent Probes and Labeling Technologies, 11th edn., I. Johnson and M. T. Z. Spence, eds., Invitrogen Corp., Carlsbad, CA (USA), 2010 or visit the web site of Thermo Fisher Scientific (reference 31).

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