3β-Isoobeticholic acid efficiently activates the farnesoid X receptor (FXR) due to its epimerization to 3α-epimer by hepatic metabolism-Reference-Cited by-同舟云学术

3β-Isoobeticholic acid efficiently activates the farnesoid X receptor (FXR) due to its epimerization to 3α-epimer by hepatic metabolism

Published:2020-09 Issue: Volume:202 Page:105702
ISSN:0960-0760
Container-title:The Journal of Steroid Biochemistry and Molecular Biology
language:en
Short-container-title:The Journal of Steroid Biochemistry and Molecular Biology

Author:

Stefela Alzbeta,Kaspar Miroslav,Drastik Martin,Holas Ondrej,Hroch Milos,Smutny Tomas,Skoda Josef,Hutníková Miriama,Pandey Amit V.,Micuda Stanislav,Kudova Eva,Pavek Petr

Funder

institutional grants Progress

InoMed project

Czech Scientific Agency GACR

GAUK

Technology Agency of the Czech Republic: Czech National Centres of Competence, project’ ’PerMed “Personalized Medicine – Diagnostics and Therapy

Academy of Sciences of the Czech Republic (AS CR) – grant

Publisher

Elsevier BV

Subject

Cell Biology,Clinical Biochemistry,Endocrinology,Molecular Biology,Molecular Medicine,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference63 articles.

1. Identification of a nuclear receptor for bile acids;Makishima;Science,1999

2. Vitamin D receptor as an intestinal bile acid sensor;Makishima;Science,2002

3. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity;Staudinger;Proc Natl Acad Sci U S A,2001

4. Developments in bile salt based therapies: a critical overview;Donkers;Biochem. Pharmacol.,2019

5. Chemistry and pharmacology of GPBAR1 and FXR selective agonists, dual agonists, and antagonists;De Marino;Handb. Exp. Pharmacol.,2019

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5. (E)-7-Ethylidene-lithocholic Acid (7-ELCA) Is a Potent Dual Farnesoid X Receptor (FXR) Antagonist and GPBAR1 Agonist Inhibiting FXR-Induced Gene Expression in Hepatocytes and Stimulating Glucagon-like Peptide-1 Secretion From Enteroendocrine Cells;Frontiers in Pharmacology;2021-08-13