The 11β-hydroxysteroid dehydrogenase isoforms: pivotal catalytic activities yield potent C11-oxy C19 steroids with 11βHSD2 favouring 11-ketotestosterone, 11-ketoandrostenedione and 11-ketoprogesterone biosynthesis

Author:

Gent Rachelle,du Toit Therina,Bloem Liezl M.,Swart Amanda C.

Funder

National Research Foundation

Harry Crossley Foundation

Stellenbosch University

Publisher

Elsevier BV

Subject

Cell Biology,Clinical Biochemistry,Endocrinology,Molecular Biology,Molecular Medicine,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference34 articles.

1. The human gene for 11ß-hydroxysteroid dehydrogenase: structure, tissue distribution, and chromosomal localization;Tannin;J. Biol. Chem.,1991

2. 11β-hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess;White;Endocr. Rev.,1997

3. 11β-hydroxyandrostenedione returns to the steroid arena: biosynthesis, metabolism and function;Bloem;Molecules,2013

4. 11β-hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolized in LNCaP cells by 5α-reductase yielding 11β-hydroxy-5α-androstanedione;Swart;J. Steroid Biochem. Mol. Biol.,2013

5. 11-Ketotestosterone and 11-ketodihydrotestosterone in castration resistant prostate cancer: potent androgens which can no longer be ignored;Pretorius;PLoS One,2016

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