Vitamin D (1,25(OH)2D3) induces α-1-antitrypsin synthesis by CD4+ T cells, which is required for 1,25(OH)2D3-driven IL-10

Author:

Dimeloe Sarah,Rice Louise V.,Chen Hebe,Cheadle Charlotte,Raynes John,Pfeffer PaulORCID,Lavender Paul,Richards David F.,Nyon Mun Peak,McDonnell James M.,Kemper Claudia,Gooptu BibekORCID,Hawrylowicz Catherine M.ORCID

Funder

MRC & Asthma UK Centre for Allergic Mechanisms of Asthma

MRC Research Grant

Medical Research Council Centre for Transplantation

Alpha-1 Foundation

Department of Health, National Institute for Health Research

Publisher

Elsevier BV

Subject

Cell Biology,Clinical Biochemistry,Endocrinology,Molecular Biology,Molecular Medicine,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference42 articles.

1. Regulation of immune function by vitamin d and its use in diseases of immunity;Vanherwegen;Endocrinol. Metab. Clin. North Am.,2017

2. 1alpha,25-dihydroxyvitamin D3 promotes CD200 expression by human peripheral and airway-resident T cells;Dimeloe;Thorax,2012

3. The role of 1alpha,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+ and IL-10+ CD4+ T cells;Urry;Eur. J. Immunol.,2012

4. Ligation of TLR9 induced on human IL-10-secreting Tregs by 1alpha,25-dihydroxyvitamin D3 abrogates regulatory function;Urry;J. Clin. Invest.,2009

5. Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients;Xystrakis;J. Clin. Invest.,2006

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