Dutasteride affects progesterone metabolizing enzyme activity/expression in human breast cell lines resulting in suppression of cell proliferation and detachment

Author:

Wiebe J.P.,Souter L.,Zhang G.

Publisher

Elsevier BV

Subject

Cell Biology,Clinical Biochemistry,Endocrinology,Molecular Biology,Molecular Medicine,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference28 articles.

1. The 4-pregnene and 5α-pregnane progesterone metabolites formed in non-tumourous and tumourous breast tissue have opposite effect on breast cell proliferation and adhesion;Wiebe;Cancer Res.,2000

2. Activity and expression of progesterone metabolizing 5α-reductase, 20α-hydroxysteroid oxidoredutase and 3α(β)-hydroxysteroid oxidoredutases in tumourigenic (MCF-7, MDA-MB-231, T-47D) and nontumorigenic (MCF-10A) human breast cancer cells;Wiebe;BMC Cancer,2003

3. The endogenous progesterone metabolite, 5α-pregnane-3,20-dione, decreases cell-substrate attachment, adhesion plaques, vinculin expression, and polymerized f-actin in MCF-7 breast cancer cells;Wiebe;Endocrine,2001

4. The role of progesterone metabolites in breast cancer: potential for new diagnostics and therapeutics;Wiebe;J. Steroid Biochem. Mol. Biol.,2005

5. Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma;Lewis;BMC Cancer,2004

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