Simeprevir plus sofosbuvir, with or without ribavirin, to treat chronic infection with hepatitis C virus genotype 1 in non-responders to pegylated interferon and ribavirin and treatment-naive patients: the COSMOS randomised study

Author:

Lawitz Eric,Sulkowski Mark S,Ghalib Reem,Rodriguez-Torres Maribel,Younossi Zobair M,Corregidor Ana,DeJesus Edwin,Pearlman Brian,Rabinovitz Mordechai,Gitlin Norman,Lim Joseph K,Pockros Paul J,Scott John D,Fevery Bart,Lambrecht Tom,Ouwerkerk-Mahadevan Sivi,Callewaert Katleen,Symonds William T,Picchio Gaston,Lindsay Karen L,Beumont Maria,Jacobson Ira M

Publisher

Elsevier BV

Subject

General Medicine

Reference17 articles.

1. Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection;McHutchison;N Engl J Med,2009

2. Simeprevir with peginterferon alfa 2a or 2b plus ribavirin in treatment-naive patients with hepatitis C virus genotype 1 infection (QUEST-2): a randomised, double-blind, placebo-controlled, phase 3 trial;Manns;Lancet,2014

3. Simeprevir with pegylated interferonalfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1): a phase 3, randomised, double-blind, placebo-controlled trial;Jacobson;Lancet,2014

4. Simeprevir with peginterferon and ribavirin leads to high rates of SVR in patients with HCV genotype 1 who relapsed after previous therapy: a phase 3 trial;Forns;Gastroenterology,2014

5. Reddy KR, Zeuzem S, Zoulim F, et al. A Phase III randomised, double-blind study to evaluate the efficacy, safety and tolerability of simeprevir vs telaprevir in combination with pegylated interferon and ribavirin in chronic hepatitis C virus genotype 1 treatment-experienced patients: the ATTAIN study. Asian Pacific Association for Study of the Liver (APASL); Brisbane, Australia; March 12–15, 2014.

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