Hand Transplantation: The State-of-the-Art

Author:

SCHUIND F.1,ABRAMOWICZ D.1,SCHNEEBERGER S.1

Affiliation:

1. From the Service d’Orthopédie-Traumatologie and Service de Néphrologie, Cliniques Universitaires de Bruxelles, Hôpital Erasme, 808 route de Lennik, B-1070, Brussels, Belgium and Department of Transplantation Surgery, University Hospital, Anichstrasse 35, Innsbruck, Austria

Abstract

The feasibility of hand transplantation has been demonstrated, both surgically and immunologically. Levels of immunosuppression comparable to regimens used in solid organ transplantation are proving sufficient to prevent graft loss. Many patients have achieved discriminative sensibility and recovery of intrinsic muscle function. In addition to restoration of function, hand transplantation offers considerable psychological benefits. The recipient’s pre-operative psychological status, his motivation and his compliance with the intense rehabilitation programme are key issues. While the induction of graft specific tolerance represents a hope for the future, immunosuppression currently remains necessary and carries significant risks. Hand transplantation should, therefore, only be considered a therapeutic option for a carefully selected group of patients.

Publisher

SAGE Publications

Subject

Surgery

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