The phosphoinositide 3-kinase inhibitor alpelisib restores actin organization and improves proximal tubule dysfunction in vitro and in a mouse model of Lowe syndrome and Dent disease
Author:
Funder
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Wellcome Trust
Cancer Research UK
Publisher
Elsevier BV
Subject
Nephrology
Reference34 articles.
1. Learning physiology from inherited kidney disorders;van der Wijst;Physiol Rev,2019
2. Lowe syndrome;Loi;Orphanet J Rare Dis,2006
3. Lowe syndrome;Lewis,1993
4. The 5-phosphatase OCRL in Lowe syndrome and Dent disease 2;De Matteis;Nat Rev Nephrol,2017
5. Chloride transporters and receptor-mediated endocytosis in the renal proximal tubule;Devuyst;J Physiol,2015
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