Antibody aggregation can lead to reduced Protein A binding capacity and low step yield
Author:
Publisher
Elsevier BV
Subject
Biotechnology
Reference7 articles.
1. Alternative molecular formats and therapeutic applications for bispecific antibodies;Spiess;Mol. Immunol.,2015
2. Fabs-in-tandem immunoglobulin is a novel and versatile bispecific design for engaging multiple therapeutic targets;Gong;mAbs,2017
3. Development of tetravalent, bispecific CCR5 antibodies with antiviral activity against CCR5 monoclonal antibody-resistant HIV-1 strains;Schanzer;Antimicrob. Agents Chemother.,2011
4. Protein A chromatography: challenges and progress in the purification of monoclonal antibodies;Ramos-de-la-Peña;J. Separ. Sci.,2019
5. Evaluation of recent Protein A stationary phase innovations for capture of biotherapeutics;Pabst;J. Chromatogr. A,2018
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1. Effects of molecule hydrophobicity and structural flexibility of appended bispecific antibody on Protein A chromatography;Journal of Chromatography A;2024-08
2. Unravelling the reason for different binding behaviors exhibited by antibody aggregates towards preparative and analytical Protein A columns;Protein Expression and Purification;2024-06
3. SEC-HPLC analysis of column load and flow-through provides critical understanding of low Protein A step yield;Protein Expression and Purification;2024-04
4. Acidic pH or salt treatment can convert soluble antibody aggregates in culture harvest into monomers and improve Protein A chromatography step yield;Protein Expression and Purification;2024-03
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