Sustained release of injectable zinc-recombinant hirudin suspensions: development and validation of in vitro release model

Author:

Gietz Ursula,Arvinte Tudor,Mader Evelyn,Oroszlan Peter,Merkle Hans P

Publisher

Elsevier BV

Subject

Pharmaceutical Science,General Medicine,Biotechnology

Reference14 articles.

1. Kinetics of the inhibition of thrombin by hirudin;Stone;Biochemistry,1986

2. Selective thrombin inhibitors: next generation of anticoagulants;Deutsch;J. Am. Coll. Cardiol.,1993

3. T. Arvinte, Pharmaceutical compositions containing hirudin. Eur. Patent 0624375A2 (1994).

4. U. Gietz, T. Arvinte, H.P. Merkle, Preformulation aspects of hirudin: pH dependent co-precipitation of hirudin and zinc, in: Proc. 1st World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Budapest, Hungary, 1995, pp. 54–55.

5. An in vitro test for the duration of action of insulin suspensions;Graham;J. Pharm. Pharmacol.,1984

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