Bcl-xL is required for the protective effects of low-dose berberine against doxorubicin-induced cardiotoxicity through blocking apoptosis and activating mitophagy-mediated ROS elimination

Author:

Chen Bo,Zhang Jing-Pu

Funder

Chinese Academy of Meteorological Sciences

Foundation for Innovative Research Groups of the National Natural Science Foundation of China

CAMS Innovation Fund for Medical Sciences

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine

Reference47 articles.

1. Hormetic Effect of Berberine Attenuates the Anticancer Activity of Chemotherapeutic Agents;Bao;PLoS One,2015

2. Doxorubicin impairs cardiomyocyte viability by suppressing transcription factor EB expression and disrupting autophagy;Bartlett;Biochem. J.,2016

3. Embryo and Developmental Toxicity of Cefazolin Sodium Impurities in Zebrafish;Chen;Front. Pharmacol.,2017

4. Three-dimensional integrated quantitative modeling and fluorescent imaging of doxorubicin-induced cardiotoxicity in a whole organ using a deconvolution microscope;Chen;J. Pharmacol. Toxicol. Methods,2019

5. Protective effect of berberine on doxorubicininduced acute hepatorenal toxicity in rats;Chen;Mol Med Rep,2016

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